没事，我就来水水

电脑一句一经验，真的累

Total synthesis of ciguatoxins (Figure 1), the causative neuro￾toxins of ciguatera seafood poisoning,1–4 has been a formida￾ble challenge in organic synthesis, and is expected to have an
impact on studies of the voltage-sensitive sodium ion channel
(VSSC) and the development of an immunoassay, which have
been impeded by the extreme difficulty in isolating ciguatox￾ins. Thus, chemical synthesis has been the sole realistic solu￾tion available for obtaining sufficient quantities of ciguatoxins
for these studies. There was little prospect of success for total
synthesis of ciguatoxins when we first launched our endeavors
towards synthesizing these fascinating and gigantic molecules
in 1989.5 However, our efforts culminated in the first total syn￾thesis of ciguatoxin CTX3C (1)6 in 2001.7,8